DDIS-03. EGFR AMPLIFICATION INDUCED INCREASED DNA DAMAGE RESPONSE AND PREDICTED SELECTIVE SENSITIVITY TO TALAZOPARIB (PARP INHIBITOR) IN GLIOBLASTOMA STEM-LIKE CELLS

Poly-ADP-ribose polymerase (PARP) is an enzyme critical for regulating a variety of DNA damage repair mechanisms. In this study, we report that PARP inhibitor, talazoparib, showed strong single-agent cytotoxicity and remarkable selective activity in glioma stem-like cells (GSCs). This single agent a...

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Publicado en:Neuro Oncol
Main Authors: Wu, Shaofang, Gao, Feng, Zheng, Siyuan, Zhang, Chen, Martinez-Ledesma, Juan Emmanuel, Ezhilarasan, Ravesanker, Ding, Jie, Li, Xiaolong, Feng, Ningping, Sulman, Erik, Verhaak, Roel, de Groot, John, Heffernan, Tim, Yung, W K Alfred, Koul, Dimpy
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Abstracts
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217227/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.282
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