16-Hydroxycleroda-3,13-dien-15,16-olide induces anoikis in human renal cell carcinoma cells: involvement of focal adhesion disassembly and signaling

BACKGROUND: Clerodane diterpene, 16-hydroxycleroda-3,13-dien-15,16-olide (CD) isolated from Polyalthia longifolia Benth. & Hook. f. var. pendula was found to be a potential apoptotic inducer in human leukemia, lung cancer, and colon cancer cells. However, the molecular mechanism remains elusive...

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Detalles Bibliográficos
Publicado en:Onco Targets Ther
Main Authors: Chen, Yu-Chi, Huang, Bu-Miin, Lee, Wei-Chang, Chen, Yung-Chia
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2018
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217210/
https://ncbi.nlm.nih.gov/pubmed/30464516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S173378
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