PDCT-04. PHASE 1 TRIAL OF WEE1 KINASE INHIBITOR AZD1775 COMBINED WITH RADIATION THERAPY FOR CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP PHASE 1 PILOT CONSORTIUM (ADVL1217)

OBJECTIVES: Children with diffuse intrinsic pontine glioma (DIPG) continue to have a dismal outcome and median survival remains stagnant at 9 months for decades. AZD1775 is an orally available inhibitor of Wee1 kinase, a key G2-M checkpoint regulator that has been shown to cross the blood brain barr...

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Publicado no:Neuro Oncol
Main Authors: Mueller, Sabine, Yang, Xiaodong, Pal, Sharmistha, Ermioian, Ralph, Fox, Elizabeth, Gajjar, Amar, Minard, Charles, Liu, Xiaowei, Prem, Komal, Reid, Joel, Weigel, Brenda, Haas-Kogan, Daphne
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217017/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.834
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