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EXTH-07. DESIGN AND EVALUATION OF WP1122, AN INHIBITOR OF GLYCOLYSIS WITH INCREASED CNS UPTAKE.
Glioblastoma (GBM), an aggressive primary brain tumor, relies on anaerobic glycolysis to produce energy. A known inhibitor of glycolysis, 2-deoxy-D-glucose (2-DG) has been clinically tested but its poor drug-like characteristics limited its practical application for cancer treatment. To overcome thi...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216990/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.356 |
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