CBMT-06. LOWER GRADE ISOCITRATE DEHYDROGENASE (IDH) MUTANT GLIOMAS METABOLICALLY MIMICKING GLIOBLASTOMA (GBM) EXPRESS HIGHER R:S 2-HYDROXYGLUTARATE RATIOS RELATIVE TO NON-GBM-MIMICKING IDH MUTANT GLIOMAS

BACKGROUND: Glioma patients continue to carry a very poor prognosis despite maximal therapy, urging for the development of novel therapies. Previous studies have identified mutations of metabolic enzymes directly regulating cellular metabolism, specifically, isocitrate dehydrogenase (IDH1/2) mutatio...

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Published in:Neuro Oncol
Main Authors: Nejad, Romina, Nassiri, Farshad, Mamatjan, Yasin, Sim, Hao-Wen, Chen, Eric, Agnihotri, Sameer, Aldape, Kenneth, Zadeh, Gelareh
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216969/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.125
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