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Geometry of the Sample Frequency Spectrum and the Perils of Demographic Inference

The sample frequency spectrum (SFS), which describes the distribution of mutant alleles in a sample of DNA sequences, is a widely used summary statistic in population genetics. The expected SFS has a strong dependence on the historical population demography and this property is exploited by popular...

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Vydáno v:Genetics
Hlavní autoři: Rosen, Zvi, Bhaskar, Anand, Roch, Sebastien, Song, Yun S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216588/
https://ncbi.nlm.nih.gov/pubmed/30064984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.118.300733
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