IMMU-57. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION

Heterogeneous expression of target antigens can allow tumor escape from chimeric antigen receptor-transduced T-cell (CART) therapy targeting a single antigen. While epidermal growth factor receptor (EGFR)vIII represents a glioblastoma (GBM)-specific antigen, its expression is heterogeneous within th...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Watchmaker, Payal, Choe, Joseph, Carrera, Diego, Downey, Kira, Shahin, Maryam, Roybal, Kole, Lim, Wendell, Okada, Hideho
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216573/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.560
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