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ACTR-47. PATIENTS WITH EGFR AMPLIFICATION BUT WITHOUT EGFRvIII EXPRESSION HAVE IMPROVED BENEFIT COMPARED TO THOSE WITH EGFRvIII EXPRESSION IN SAMPLES OF THE INTELLANCE 2/EORTC 1410 RANDOMIZED PHASE II TRIAL
BACKGROUND: A randomized phaseII trial on EGFR-amplified recurrent glioblastomas showed that Depatux-M+TMZ improves overall survival compared to the single agent control arms. We performed targeted next-generation-sequencing to identify patients that benefit from the combination. METHODS: DNA and RN...
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| Udgivet i: | Neuro Oncol |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216397/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.079 |
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