ACTR-39. TWO-YEAR RESULTS OF THE INTELLANCE 2/EORTC TRIAL 1410 RANDOMIZED PHASE II STUDY ON DEPATUX–M ALONE, DEPATUX-M COMBINED WITH TEMOZOLOMIDE (TMZ) AND EITHER TMZ OR LOMUSTINE IN RECURRENT EGFR AMPLIFIED GLIOBLASTOMA (NCT02343406

BACKGROUND: Depatux-M is an antibody-drug-conjugate consisting of an antibody (ABT-806) specific to the activated conformation of EGFR bound to the toxin monomethylauristatin-F. In the primary analysis on EORTC 1410 we reported a trend (p = 0.06) towards improved overall survival (OS) in patients wi...

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Publicado no:Neuro Oncol
Main Authors: van den Bent, Martin, French, Pim, Eoli, Marica, Sepulveda, Juan, Walenkamp, Annemiek, Frenel, Jean-Sebastian, Franceschi, Enrico, Clement, Paul, Weller, Michael, de Heer, Iris, Looman, Jim, Dey, Jyotirmoy, Krause, Scott, Xiong, Hao, Ansell, Peter, Nuyens, Sarah, Brilhante, Joana, Spruyt, Maarten, Gorlia, Thierry, Golfinopoulos, Vassilis
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216361/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.072
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