STEM-23. miR-486-5p REGULATES TUMOR SUPPRESSOR NETWORKS AND ITS INHIBITION REDUCES TUMOR VOLUME AND SENSITIZES TO RADIATION TREATMENT IN A PDX MOUSE MODEL OF GBM

Glioblastoma multiforme (GBM) is a heterogeneous malignancy that contains a subpopulation of tumor cells with stem-like features. These GBM stem cells (GSCs) have the ability to self-renew and establish tumors. As such, they are thought to disproportionately contribute to re-growth and resistance to...

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Pubblicato in:Neuro Oncol
Autori principali: Kotchetkov, Ivan, Lopez-Berotni, Hernando, Michelson, Nicole, Rui, Yuan, Lal, Bachchu, Li, Yunqing, Green, Jordan, Laterra, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216229/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1030
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