ATIM-16. PHASE 1 STUDY RESULTS OF M7824 (MSB0011359C), A BIFUNCTIONAL FUSION PROTEIN TARGETING TGF- AND PD-L1, AMONG PATIENTS WITH RECURRENT GLIOBLASTOMA (rGBM)

BACKGROUND: TGF- signaling promotes tumor immunosuppression; TGF- inhibition in the tumor microenvironment may enhance the response to antiPD-L1 treatment. M7824 is an innovative, first-in-class, bifunctional fusion protein composed of a human antiPD-L1 IgG1 monoclonal antibody fused with two extrac...

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Publicado no:Neuro Oncol
Main Authors: Khasraw, Mustafa, Weller, Michael, Estelles, David Lorente, Kolibaba, Kathryn, Lee, Chee, Gedye, Craig, De La Fuente, Macarena, Vicente, David, Reardon, David, Ojalvo, Laureen, Helwig, Christoph, Gourmelon, Carole, Groves, Morris
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216129/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.011
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