Pancreatic Islet-Autonomous Insulin and Smoothened-Mediated Signaling Modulate Identity Changes of Glucagon(+) α-Cells

The mechanisms restricting regeneration and maintaining cell identity following injury are poorly characterized in higher vertebrates. Upon β-cell loss, 1–2% of the glucagon-producing α-cells spontaneously engage in insulin production in mice. Here we explore the mechanisms inhibiting α-cell plastic...

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Publicado no:Nat Cell Biol
Main Authors: Cigliola, Valentina, Ghila, Luiza, Thorel, Fabrizio, van Gurp, Léon, Baronnier, Delphine, Oropeza, Daniel, Gupta, Simone, Miyatsuka, Takeshi, Kaneto, Hideaki, Magnuson, Mark A., Osipovich, Anna B., Sander, Maike, Wright, Christopher V. E., Thomas, Melissa K., Furuyama, Kenichiro, Chera, Simona, Herrera, Pedro L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215453/
https://ncbi.nlm.nih.gov/pubmed/30361701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0216-y
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