Pancreatic Islet-Autonomous Insulin and Smoothened-Mediated Signaling Modulate Identity Changes of Glucagon(+) α-Cells

The mechanisms restricting regeneration and maintaining cell identity following injury are poorly characterized in higher vertebrates. Upon β-cell loss, 1–2% of the glucagon-producing α-cells spontaneously engage in insulin production in mice. Here we explore the mechanisms inhibiting α-cell plastic...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Cigliola, Valentina, Ghila, Luiza, Thorel, Fabrizio, van Gurp, Léon, Baronnier, Delphine, Oropeza, Daniel, Gupta, Simone, Miyatsuka, Takeshi, Kaneto, Hideaki, Magnuson, Mark A., Osipovich, Anna B., Sander, Maike, Wright, Christopher V. E., Thomas, Melissa K., Furuyama, Kenichiro, Chera, Simona, Herrera, Pedro L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215453/
https://ncbi.nlm.nih.gov/pubmed/30361701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0216-y
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