ALK Fusion Partners Impact Response to ALK Inhibition: Differential Effects on Sensitivity, Cellular Phenotypes, and Biochemical Properties

Oncogenic tyrosine kinase fusions involving the anaplastic lymphoma kinase (ALK) are detected in numerous tumor types. Although more than 30 distinct 5’ fusion partner genes have been reported, treatment of ALK-rearranged cancers is decided without regard to which 5’ partner is present. There is lit...

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Bibliographic Details
Published in:Mol Cancer Res
Main Authors: Childress, Merrida A., Himmelberg, Stephen M., Chen, Huiqin, Deng, Wanleng, Davies, Michael A., Lovly, Christine M.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214753/
https://ncbi.nlm.nih.gov/pubmed/30002191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0171
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