Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of anti-PD-1 Therapies in Metastatic Melanoma

PURPOSE: PD-1/L1 axis-directed therapies produce clinical responses in a subset of patients, therefore, biomarkers of response are needed. We hypothesized quantifying key immunosuppression mechanisms within the tumor microenvironment by multiparameter algorithms would identify strong predictors of a...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Johnson, Douglas B., Bordeaux, Jennifer, Kim, Ju Young, Vaupel, Christine, Rimm, David L., Ho, Thai H., Joseph, Richard W, Daud, Adil I., Conry, Robert M., Gaughan, Elizabeth M., Hernandez-Aya, Leonel F., Dimou, Anastasios, Funchain, Pauline, Smithy, James, Witte, John S., McKee, Svetlana B., Ko, Jennifer, Wrangle, John M., Dabbas, Bashar, Tangri, Shabnam, Lameh, Jelveh, Hall, Jeffrey, Markowitz, Joseph, Balko, Justin M., Dakappagari, Naveen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214750/
https://ncbi.nlm.nih.gov/pubmed/30021908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0309
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