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Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of anti-PD-1 Therapies in Metastatic Melanoma
PURPOSE: PD-1/L1 axis-directed therapies produce clinical responses in a subset of patients, therefore, biomarkers of response are needed. We hypothesized quantifying key immunosuppression mechanisms within the tumor microenvironment by multiparameter algorithms would identify strong predictors of a...
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| Vydáno v: | Clin Cancer Res |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6214750/ https://ncbi.nlm.nih.gov/pubmed/30021908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0309 |
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