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Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation

Self‐renewal of embryonic stem cells (ESCs) cultured in LIF/fetal calf serum (FCS) is incomplete with some cells initiating differentiation. While this is reflected in heterogeneous expression of naive pluripotency transcription factors (TFs), the link between TF heterogeneity and differentiation is...

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Bibliografiset tiedot
Julkaisussa:EMBO J
Päätekijät: Festuccia, Nicola, Halbritter, Florian, Corsinotti, Andrea, Gagliardi, Alessia, Colby, Douglas, Tomlinson, Simon R, Chambers, Ian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213284/
https://ncbi.nlm.nih.gov/pubmed/30275266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695476
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