Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs

An enhanced indoleamine 2,3-dioxygenase 1 (IDO1) activity is associated with an increased mortality risk in sepsis patients. Thus, the preventive inhibition of IDO1 activity may be a promising strategy to attenuate the severity of septic shock. 1-methyltryptophan (1-MT) is currently in the interest...

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發表在:Int J Mol Sci
Main Authors: Wirthgen, Elisa, Otten, Winfried, Tuchscherer, Margret, Tuchscherer, Armin, Domanska, Grazyna, Brenmoehl, Julia, Günther, Juliane, Ohde, Daniela, Weitschies, Werner, Seidlitz, Anne, Scheuch, Eberhard, Kanitz, Ellen
格式: Artigo
語言:Inglês
出版: MDPI 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213023/
https://ncbi.nlm.nih.gov/pubmed/30279361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19103009
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