Aberrant PRDM9 expression impacts the pan-cancer genomic landscape

The binding of PRDM9 to chromatin is a key step in the induction of DNA double-strand breaks associated with meiotic recombination hotspots; it is normally expressed solely in germ cells. We interrogated 1879 cancer samples in 39 different cancer types and found that PRDM9 is unexpectedly expressed...

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Опубликовано в: :Genome Res
Главные авторы: Houle, Armande Ang, Gibling, Heather, Lamaze, Fabien C., Edgington, Hilary A., Soave, David, Fave, Marie-Julie, Agbessi, Mawusse, Bruat, Vanessa, Stein, Lincoln D., Awadalla, Philip
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2018
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211651/
https://ncbi.nlm.nih.gov/pubmed/30341163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.231696.117
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