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An enantioselective synthesis of the core unit of the non-nucleoside reverse transcriptase inhibitor taurospongin A
An enantioselective formal synthesis of taurospongin A has been achieved. The key steps involve chelation-controlled reductions of β-ketosulfoxide and β-hydroxy ketone intermediates and Sharpless asymmetric epoxidation to construct the tertiary alcohol stereoselectively.
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| Publicat a: | Tetrahedron Asymmetry |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6211187/ https://ncbi.nlm.nih.gov/pubmed/30393445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0957-4166(03)00040-5 |
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