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An enantioselective synthesis of the core unit of the non-nucleoside reverse transcriptase inhibitor taurospongin A

An enantioselective formal synthesis of taurospongin A has been achieved. The key steps involve chelation-controlled reductions of β-ketosulfoxide and β-hydroxy ketone intermediates and Sharpless asymmetric epoxidation to construct the tertiary alcohol stereoselectively.

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Dades bibliogràfiques
Publicat a:Tetrahedron Asymmetry
Autors principals: Ghosh, Arun K., Lei, Hui
Format: Artigo
Idioma:Inglês
Publicat: 2003
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211187/
https://ncbi.nlm.nih.gov/pubmed/30393445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0957-4166(03)00040-5
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