Next-Generation Sequencing and Quantitative Proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging

Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the molecular mechanisms underlying HGPS are still not fully understood and, currently, there...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mateos, Jesús, Fafián-Labora, Juan, Morente-López, Miriam, Lesende-Rodriguez, Iván, Monserrat, Lorenzo, Ódena, María A., de Oliveira, Eliandre, de Toro, Javier, Arufe, María C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6209416/
https://ncbi.nlm.nih.gov/pubmed/30379953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205878
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