Clinical impact of intratumoral HER2 heterogeneity on trastuzumab efficacy in patients with HER2-positive gastric cancer

BACKGROUND: There is growing interest in the clinical significance of intratumoral HER2 heterogeneity. Its prognostic and predictive impacts on trastuzumab efficacy were demonstrated in breast cancer. However, its clinical significance in gastric cancer is still unclear. METHODS: Twenty-eight HER2-p...

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Dettagli Bibliografici
Pubblicato in:J Gastroenterol
Autori principali: Wakatsuki, Takeru, Yamamoto, Noriko, Sano, Takeshi, Chin, Keisho, Kawachi, Hiroshi, Takahari, Daisuke, Ogura, Mariko, Ichimura, Takashi, Nakayama, Izuma, Osumi, Hiroki, Matsushima, Tomohiro, Suenaga, Mitsukuni, Shinozaki, Eiji, Hiki, Naoki, Ishikawa, Yuichi, Yamaguchi, Kensei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Japan 2018
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Original Article—Alimentary Tract
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6209002/
https://ncbi.nlm.nih.gov/pubmed/29633013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-018-1464-0
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