Genetic polymorphisms of 3′-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy

PURPOSE: Tamoxifen has a wide inter-variability. Recently, two SNPs in the 3′-untranslated region (UTR) of the SULT1A1 gene, rs6839 and rs1042157, have been associated with decreased SULT1A1 activity. The aim of this study is to investigate the role of the rs6839 and rs1042157 on tamoxifen metabolis...

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Bibliographic Details
Published in:Breast Cancer Res Treat
Main Authors: Sanchez-Spitman, A. B., Dezentjé, V. O., Swen, J. J., Moes, D. J. A. R., Gelderblom, H., Guchelaar, Henk-Jan
Format: Artigo
Language:Inglês
Published: Springer US 2018
Subjects:
Clinical Trial
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208901/
https://ncbi.nlm.nih.gov/pubmed/30120701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-018-4923-7
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