PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma

Transcriptional deregulation has a vital role in glioblastoma multiforme (GBM). Thus, identification of epigenetic modifiers essential for oncogenic transcriptional programs is a key to designing effective therapeutics for this deadly disease. Here we report that Protein Arginine Methyltransferase 2...

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Udgivet i:Nat Commun
Main Authors: Dong, Feng, Li, Qian, Yang, Chao, Huo, Dawei, Wang, Xing, Ai, Chunbo, Kong, Yu, Sun, Xiaoyu, Wang, Wen, Zhou, Yan, Liu, Xing, Li, Wei, Gao, Weiwei, Liu, Wen, Kang, Chunsheng, Wu, Xudong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208368/
https://ncbi.nlm.nih.gov/pubmed/30382083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06968-7
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