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Metabolic Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes by Inhibition of HIF1α and LDHA

RATIONALE: Human Pluripotent Stem Cell-Derived Cardiomyocytes (hPSC-CMs) are a readily available, robustly reproducible and physiologically appropriate human cell source for cardiac disease modeling, drug discovery, and toxicity screenings in vitro. However, unlike adult myocardial cells in vivo, hP...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Hu, Dongjian, Linders, Annet, Yamak, Abir, Correia, Cláudia, Kijlstra, Jan David, Garakani, Arman, Xiao, Ling, Milan, David J., van der Meer, Peter, Serra, Margarida, Alves, Paula M., Domian, Ibrahim J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208155/
https://ncbi.nlm.nih.gov/pubmed/30355156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.313249
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