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Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury
Significance: After approximatelty three decades of research, two Mn(III) porphyrins (MnPs), MnTE-2-PyP(5+) (BMX-010, AEOL10113) and MnTnBuOE-2-PyP(5+) (BMX-001), have progressed to five clinical trials. In parallel, another similarly potent metal-based superoxide dismutase (SOD) mimic—Mn(II)pentaaz...
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| 發表在: | Antioxid Redox Signal |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Mary Ann Liebert, Inc., publishers
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6207162/ https://ncbi.nlm.nih.gov/pubmed/29926755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2017.7453 |
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