A Pharmacochaperone-Based High-Throughput Screening Assay for the Discovery of Chemical Probes of Orphan Receptors

G-protein-coupled receptors (GPCRs) have varying and diverse physiological roles, transmitting signals from a range of stimuli, including light, chemicals, peptides, and mechanical forces. More than 130 GPCRs are orphan receptors (i.e., their endogenous ligands are unknown), representing a large unt...

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Detalhes bibliográficos
Publicado no:Assay Drug Dev Technol
Main Authors: Morfa, Camilo J., Bassoni, Daniel, Szabo, Andras, McAnally, Danielle, Sharir, Haleli, Hood, Becky L., Vasile, Stefan, Wehrman, Tom, Lamerdin, Jane, Smith, Layton H.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207161/
https://ncbi.nlm.nih.gov/pubmed/30251873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2018.868
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