Massive NGS data analysis reveals hundreds of potential novel gene fusions in human cell lines

BACKGROUND: Gene fusions derive from chromosomal rearrangements. The resulting chimeric transcripts are often endowed with oncogenic potential. Furthermore, they serve as diagnostic tools for the clinical classification of cancer subgroups with different prognosis and, in some cases, they can provid...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Gigascience
Hauptverfasser: Gioiosa, Silvia, Bolis, Marco, Flati, Tiziano, Massini, Annalisa, Garattini, Enrico, Chillemi, Giovanni, Fratelli, Maddalena, Castrignanò, Tiziana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Data Note
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207142/
https://ncbi.nlm.nih.gov/pubmed/29860514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gigascience/giy062
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