Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging

Background: Delirium in elderly patients is common and dangerous. Major risk factors include aging and exogenous insults, such as infection or surgery. In animal models, aging enhances pro-inflammatory cytokine release from microglia in response to exogenous insults. The epigenetic mechanism DNA met...

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Gepubliceerd in:Front Aging Neurosci
Hoofdauteurs: Shinozaki, Gen, Braun, Patricia R., Hing, Benjamin W. Q., Ratanatharathorn, Andrew, Klisares, Mason J., Duncan, Gabrielle N., Jellison, Sydney S., Heinzman, Jonathan T., Nagahama, Yasunori, Close, Liesl, Sabbagh, Sayeh, Dlouhy, Brian J., Howard, Matthew A., Kawasaki, Hiroto, Cho, Hyunkeun R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206747/
https://ncbi.nlm.nih.gov/pubmed/30405391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00311
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