Synthesis and Evaluation of Baylis-Hillman Reaction Derived Imidazole and Triazole Cinnamates as Antifungal Agents

Allylic acetates derived from Baylis-Hillman reaction undergo efficient nucleophilic isomerization with imidazoles and triazoles to provide imidazolylmethyl and triazolylmethyl cinnamates stereoselectively. Antifungal evaluation of these derivatives against Cryptococcus neoformans exhibits good mini...

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Bibliografiske detaljer
Udgivet i:Int J Med Chem
Main Authors: Nelson, Grady L., Williams, Michael J., Jonnalagadda, Shirisha, Alam, Mohammad A., Mereddy, Gautam, Johnson, Joseph L., Jonnalagadda, Sravan K.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206569/
https://ncbi.nlm.nih.gov/pubmed/30410798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/5758076
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