Acidity/Alkalinity of Japanese Encephalitis Virus E Protein Residue 138 Alters Neurovirulence in Mice

The Japanese encephalitis virus (JEV) envelope (E) protein, as one of mediators of virus entry into host cells, plays a critical role in determining virulence. The Glu-to-Lys mutation of residue 138 in E protein (E138) plays an important role in attenuating JEV vaccine strain SA14-14-2. However, it...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zheng, Xuchen, Zheng, Hao, Tong, Wu, Li, Guoxin, Wang, Tao, Li, Liwei, Gao, Fei, Shan, Tongling, Yu, Hai, Zhou, Yanjun, Qiu, Yafeng, Ma, Zhiyong, Tong, Guangzhi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206487/
https://ncbi.nlm.nih.gov/pubmed/30158291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00108-18
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