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Barttin Regulates the Subcellular Localization and Posttranslational Modification of Human Cl(-)/H(+) Antiporter ClC-5

Dent disease 1 (DD1) is a renal salt-wasting tubulopathy associated with mutations in the Cl(-)/H(+) antiporter ClC-5. The disease typically manifests with proteinuria, hypercalciuria, nephrocalcinosis, and nephrolithiasis but is characterized by large phenotypic variability of no clear origin. Seve...

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Publicat a:Front Physiol
Autors principals: Wojciechowski, Daniel, Kovalchuk, Elena, Yu, Lan, Tan, Hua, Fahlke, Christoph, Stölting, Gabriel, Alekov, Alexi K.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206076/
https://ncbi.nlm.nih.gov/pubmed/30405442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01490
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