miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy

RATIONALE: Abnormal SUMOylation has emerged as a characteristic of heart failure (HF) pathology. Previously, we found reduced small ubiquitin-like modifier 1 (SUMO1) expression and sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) SUMOylation in human and animal HF models. SUMO1 gene delivery or small-...

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發表在:Circ Res
Main Authors: Oh, Jae Gyun, Watanabe, Shin, Lee, Ahyoung, Gorski, Przemek A., Lee, Philyoung, Jeong, Dongtak, Liang, Lifan, Liang, Yaxuan, Baccarini, Alessia, Sahoo, Susmita, Brown, Brian D., Hajjar, Roger J., Kho, Changwon
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205728/
https://ncbi.nlm.nih.gov/pubmed/30355233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.312751
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