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Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells

RATIONALE: Vascular malformations arise in vessels throughout the entire body. Causative genetic mutations have been identified for many of these diseases; however, little is known about the mutant cell lineage within these malformations. OBJECTIVE: We utilize an inducible mouse model of cerebral ca...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Detter, Matthew R., Snellings, Daniel A., Marchuk, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205520/
https://ncbi.nlm.nih.gov/pubmed/30359189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.313970
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