Human leukemia mutations corrupt but do not abrogate GATA-2 function

By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA-2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia. GATA2 disease m...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Katsumura, Koichi R., Mehta, Charu, Hewitt, Kyle J., Soukup, Alexandra A., Fraga de Andrade, Isabela, Ranheim, Erik A., Johnson, Kirby D., Bresnick, Emery H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205465/
https://ncbi.nlm.nih.gov/pubmed/30301799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813015115
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