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GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells
The master regulatory transcription factor GATA-2 triggers hematopoietic stem and progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and GATA2 overexpression portends a poor prognosis for AML. However, the constituen...
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| Pubblicato in: | Cell Rep |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5154384/ https://ncbi.nlm.nih.gov/pubmed/27545880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.058 |
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