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GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells

The master regulatory transcription factor GATA-2 triggers hematopoietic stem and progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and GATA2 overexpression portends a poor prognosis for AML. However, the constituen...

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Dades bibliogràfiques
Publicat a:Cell Rep
Autors principals: Katsumura, Koichi R., Ong, Irene M., DeVilbiss, Andrew W., Sanalkumar, Rajendran, Bresnick, Emery H.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154384/
https://ncbi.nlm.nih.gov/pubmed/27545880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.058
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