SUMO protease SENP1 deSUMOylates and stabilizes c-Myc

Posttranslational modifications play a crucial role in the proper control of c-Myc protein stability and activity. c-Myc can be modified by small ubiquitin-like modifier (SUMO). However, how SUMOylation regulates c-Myc stability and activity remains to be elucidated. The deSUMOylation enzyme, SENP1,...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Sun, Xiao-Xin, Chen, Yingxiao, Su, Yulong, Wang, Xiaoyan, Chauhan, Krishna Mohan, Liang, Juan, Daniel, Colin J., Sears, Rosalie C., Dai, Mu-Shui
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205424/
https://ncbi.nlm.nih.gov/pubmed/30305424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802932115
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