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The post-2009 influenza pandemic era: time to revisit antibody immunodominance
The current inactivated influenza vaccines rely on the induction of neutralizing antibodies against the head domain of the viral hemagglutinin (HA). The HA head contains five immunodominant antigenic sites, all of which are subject to antigenic drift, thereby limiting vaccine efficacy. Bypassing the...
Gespeichert in:
| Veröffentlicht in: | J Clin Invest |
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| 1. Verfasser: | |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6205375/ https://ncbi.nlm.nih.gov/pubmed/30295644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124151 |
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