Insight into novel clinical mutants of RpsA-S324F, E325K, and G341R of Mycobacterium tuberculosis associated with pyrazinamide resistance

Pyrazinamide (PZA) is an important component of first-line anti-tuberculosis drugs which is converted into active form, pyrazinoic acid (POA), by Mycobacterium tuberculosis (MTB) pncA gene encoded, pyrazinamidase (PZase). Mutations in pncA are detected in >70% of PZA resistant isolates but, notic...

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Vydáno v:Comput Struct Biotechnol J
Hlavní autoři: Khan, Muhammad Tahir, Rehaman, Ashfaq Ur, Junaid, Muhammad, Malik, Shaukat Iqbal, Wei, Dong-Qing
Médium: Artigo
Jazyk:Inglês
Vydáno: Research Network of Computational and Structural Biotechnology 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205349/
https://ncbi.nlm.nih.gov/pubmed/30402208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2018.09.004
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