PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ

Poly-ADP ribose polymerase 1 (PARP1) is clinically important because of its synthetic lethality with breast cancer allele 1 and 2 mutations, which are causative for inherited breast and ovarian cancers. Biochemically, PARP1 is a single-stranded DNA break repair protein that is needed for preserving...

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Vydáno v:Oncotarget
Hlavní autoři: Harvey, Adam, Mielke, Nicholas, Grimstead, Julia W., Jones, Rhiannon E., Nguyen, Thanh, Mueller, Matthew, Baird, Duncan M., Hendrickson, Eric A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205175/
https://ncbi.nlm.nih.gov/pubmed/30410680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26201
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