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Targeting integrin-linked kinase to suppress oncogenic KRAS signaling in pancreatic cancer
Although oncogenic KRAS represents a therapeutically relevant target in pancreatic cancer, it is deemed “non-druggable” because of the intrinsic difficulty in designing direct inhibitors of KRAS. Our recent work demonstrated a KRAS-integrin-linked kinase (ILK) regulatory feedback loop that allows pa...
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| Publicado no: | Small GTPases |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6204986/ https://ncbi.nlm.nih.gov/pubmed/27936345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2016.1251383 |
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