Enhanced gut barrier integrity sensitizes colon cancer to immune therapy

Oral IL-10 suppressed tumor growth in the APC(min/+) mouse/Bacteroides fragilis colon cancer model while a similar formulation of IL-12 exacerbated disease. In contrast, combined treatment with IL-10 and IL-12 resulted in near-complete tumor eradication and a significant extension of survival. The c...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Bhutiani, Neal, Li, Qingsheng, Anderson, Charles D., Gallagher, Heather C., De Jesus, Magdia, Singh, Rajbir, Jala, Venkatkrishna R., Fraig, Mostafa, Gu, Tao, Egilmez, Nejat K.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204984/
https://ncbi.nlm.nih.gov/pubmed/30377564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1498438
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