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Extending human IgG half-life using structure-guided design
Engineering of antibodies for improved pharmacokinetics through enhanced binding to the neonatal Fc receptor (FcRn) has been demonstrated in transgenic mice, non-human primates and humans. Traditionally, such approaches have largely relied on random mutagenesis and display formats, which fail to add...
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| Publicado no: | MAbs |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6204840/ https://ncbi.nlm.nih.gov/pubmed/29947573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1490119 |
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