Extending human IgG half-life using structure-guided design

Engineering of antibodies for improved pharmacokinetics through enhanced binding to the neonatal Fc receptor (FcRn) has been demonstrated in transgenic mice, non-human primates and humans. Traditionally, such approaches have largely relied on random mutagenesis and display formats, which fail to add...

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Vydáno v:MAbs
Hlavní autoři: Booth, Brian J., Ramakrishnan, Boopathy, Narayan, Kristin, Wollacott, Andrew M., Babcock, Gregory J., Shriver, Zachary, Viswanathan, Karthik
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204840/
https://ncbi.nlm.nih.gov/pubmed/29947573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1490119
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