In Vitro Transformation of Human Bronchial Epithelial Cells by Diesel Exhaust Particles: Gene Expression Profiling and Early Toxic Responses

Occupational exposure to diesel exhaust may cause lung cancer in humans. Mechanisms include DNA-damage and inflammatory responses. Here, the potential of NIST SRM2975 diesel exhaust particles (DEP) to transform human bronchial epithelial cells (HBEC3) in vitro was investigated. Long-term exposure of...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Rynning, Iselin, Neca, Jiri, Vrbova, Kristyna, Libalova, Helena, Rossner, Pavel, Holme, Jørn A, Gützkow, Kristine B, Afanou, Anani K Johnny, Arnoldussen, Yke J, Hruba, Eva, Skare, Øivind, Haugen, Aage, Topinka, Jan, Machala, Miroslav, Mollerup, Steen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Diesel Exhaust and Bronchial Epithelial Cell Transformation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204768/
https://ncbi.nlm.nih.gov/pubmed/30010986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy183
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