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DNA Sliding Clamps as Therapeutic Targets

Chromosomal DNA replication is achieved by an assembly of multi-protein complexes at the replication fork. DNA sliding clamps play an important role in this assembly and are essential for cell viability. Inhibitors of bacterial (β-clamp) and eukaryal DNA clamps, proliferating cell nuclear antigen (P...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Altieri, Amanda S., Kelman, Zvi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204406/
https://ncbi.nlm.nih.gov/pubmed/30406112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2018.00087
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