A carregar...

Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden, and prevents status epilepticus-induced neuronal death and epileptogenesis

OBJECTIVES: The M-current is a low threshold voltage-gated potassium current generated by Kv7 subunits that regulates neural excitation. Importantly, M-current suppression, induced by activation of Gq-coupled neurotransmitter receptors, can dynamically regulate the threshold of action potential firi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Epilepsia
Main Authors: Greene, Derek L., Kosenko, Anastasia, Hoshi, Naoto
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204291/
https://ncbi.nlm.nih.gov/pubmed/30146722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.14541
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!