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Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden, and prevents status epilepticus-induced neuronal death and epileptogenesis

OBJECTIVES: The M-current is a low threshold voltage-gated potassium current generated by Kv7 subunits that regulates neural excitation. Importantly, M-current suppression, induced by activation of Gq-coupled neurotransmitter receptors, can dynamically regulate the threshold of action potential firi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Epilepsia
Egile Nagusiak: Greene, Derek L., Kosenko, Anastasia, Hoshi, Naoto
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204291/
https://ncbi.nlm.nih.gov/pubmed/30146722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.14541
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