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Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden, and prevents status epilepticus-induced neuronal death and epileptogenesis
OBJECTIVES: The M-current is a low threshold voltage-gated potassium current generated by Kv7 subunits that regulates neural excitation. Importantly, M-current suppression, induced by activation of Gq-coupled neurotransmitter receptors, can dynamically regulate the threshold of action potential firi...
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| Publicado no: | Epilepsia |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6204291/ https://ncbi.nlm.nih.gov/pubmed/30146722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.14541 |
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