Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy

BACKGROUND: No study has evaluated the predictive and prognostic role of CD8 and PD-L1 coexpression in non–small-cell lung cancer (NSCLC). METHODS: We analyzed RNA sequencing and/or immunohistochemistry staining in NSCLC patients from The Cancer Genome Atlas (n = 1016), and 34 metastatic NSCLC sampl...

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Vydáno v:Br J Cancer
Hlavní autoři: Fumet, Jean-David, Richard, Corentin, Ledys, Fanny, Klopfenstein, Quentin, Joubert, Philippe, Routy, Bertrand, Truntzer, Caroline, Gagné, Andréanne, Hamel, Marc-André, Guimaraes, Camila Figueiredo, Coudert, Bruno, Arnould, Laurent, Favier, Laure, Lagrange, Aurélie, Ladoire, Sylvain, Saintigny, Pierre, Ortiz-Cuaran, Sandra, Perol, Maurice, Foucher, Pascal, Hofman, Paul, Ilie, Marius, Chevrier, Sandy, Boidot, Romain, Derangere, Valentin, Ghiringhelli, François
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203820/
https://ncbi.nlm.nih.gov/pubmed/30318514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0220-9
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