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Pazopanib for Renal Cell Carcinoma Leads to Elevated Mean Arterial Pressures in a Murine Model

BACKGROUND: In the setting of metastatic RCC (mRCC), pazopanib is approved as first line therapy. Unfortunately treatment may lead to cardiotoxicity such as hypertension, heart failure, and myocardial ischemia. OBJECTIVE: Define the in vivo role of pazopanib in the development of cardiotoxicity. MET...

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Detalhes bibliográficos
Publicado no:Clin Exp Hypertens
Main Authors: Kempton, Amber, Justice, Cody, Guo, Aaron, Cefalu, Matthew, Makara, Michael, Janssen, Paul, Ho, Thai H, Smith, Sakima A
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203326/
https://ncbi.nlm.nih.gov/pubmed/29172746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10641963.2017.1403623
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