Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance

BACKGROUND: Neurogenin3 (Ngn3) and neurogenic differentiation 1 (NeuroD1), two crucial transcriptional factors involved in human diabetes (OMIM: 601724) and islet development, have been previously found to directly target to the E-boxes of the insulinoma-associated 2 (Insm2) gene promoter, thereby a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Wang, Lin, Sun, Zhong Sheng, Xiang, Bingwu, Wei, Chi-ju, Wang, Yan, Sun, Kevin, Chen, Guanjie, Lan, Michael S., Carmona, Gilberto N., Notkins, Abner L., Cai, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202866/
https://ncbi.nlm.nih.gov/pubmed/30359270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1665-6
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados