LGI1 antibodies alter K(v)1.1 and AMPA receptors changing synaptic excitability, plasticity and memory

Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase domain-containing protein 23 (ADAM23), which interacts with voltage-gated potassium channels K(v)1.1, and the postsynaptic ADAM2...

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Vydáno v:Brain
Hlavní autoři: Petit-Pedrol, Mar, Sell, Josefine, Planagumà, Jesús, Mannara, Francesco, Radosevic, Marija, Haselmann, Holger, Ceanga, Mihai, Sabater, Lidia, Spatola, Marianna, Soto, David, Gasull, Xavier, Dalmau, Josep, Geis, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202570/
https://ncbi.nlm.nih.gov/pubmed/30346486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy253
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